In view of the effect of random uncertain factors such as the material properties of the turning shaft and different load conditions on its performance, and reduce its weight to improve fuel economy.Through the finite element modeling of the dump truck, the load analysis of the turning shaft is carried out according to the limit force under the actual working conditions, the first-order second moment method is used for reliability analysis, and the reliability index is used to reflect the influence of uncertain factors. The stiffness and dynamic characteristic values under static multi-conditions are set as objective functions, and the volume fraction and reliability index are used as constraints. A comprehensive objective function is established based on the normalized sub-objectives of the compromise programming method, the weight coefficients of the sub-objectives are determined by the analytic hierarchy process, and the multi-objective topology optimization design based on reliability constraints is carried out on the flip-axis structure. The results show that, compared with the deterministic topology optimization, the stiffness of the turning axis and the natural frequencies of each order obtained by the reliability topology optimization are more significantly improved, and the mass is reduced by 28.96% under the condition of satisfying the reliability. The experimental test and theoretical analysis results are basically consistent, verifying the feasibility of multi-objective reliability topology optimization design.