The fatigue crack of the wheel rims often explodes in the inclusions gathering area, and the accumulation of large inclusions will affect their fatigue life. In this article, through dynamic simulation and finite element simulation combined with material fatigue test to determine the probability of containing inclusions wheel rim method of fatigue life at different speeds. In order to estimate the fatigue life of the train wheel rim with inclusions at different speeds, the vehicle dynamics model and the wheel axle with inclusions finite element model of EMUs CRH5 were established. Then obtain the random load time history of the wheel and the stress time history of the dangerous parts at different speeds. Based on the different confidence degrees、survival rates of the S-N curve and the Miner criterion to establish fatigue life of the wheel rim containing inclusions. The results show that under the same confidence degree and survival rate, as speed increases, the fatigue life of wheel rim containing inclusions will obviously shorter; under the same speed and confidence degree, as survival rate increases, the fatigue life of wheel rim containing inclusions will obviously shorter; under the same speed and survival rate, as confidence degree increases, the fatigue life of wheel rim containing inclusions will obviously shorter.