For high-speed CAM with clearance in the process of running with reduced stability and increasing noise and wear and so on and on the basis of the characteristics of structure dynamics and kinematics, a kind of high speed CAM mechanism with clearance based on kinematics and dynamics multiple targets was put forward for optimization design. Optimization results show that we can find that the optimized CAM curves improve overall performance and part of the performance curves approach or exceed high-speed CAM common cycloid CAM curve when the three coefficients polynomial CAM curves and the standard CAM curve are compared. Among them, the weight seven variable coefficient polynomial CAM curve comprehensive performance is best and its noise is reduced accordingly. So it has higher engineering application value from these findings.